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How Alcohol Is Linked To Psoriasis In Women


Women who drink 2 or more times per week, particularly nonlight beer, are found to have a higher risk of developing psoriasis. 
This study out of Harvard University showed that the risk increased by 1.72 times normal. One hypothesis that was proposed was that non-light beer is made from wheat products, and that wheat contains gluten, which is a common component that provokes an autoimmune response in Celiac disease.

I’ve written before about how sleep apnea could cause psoriasis in men, and this situation can apply to women as well. Sleep-breathing problems at night, whether or not they’re apneas, can cause a low-grade physiologic stress response which heightens your immune system. When your body’s immune system is in a constant state of stress, it can easily attack normal tissues or proteins. Furthermore, when your body is under stress, certain parts of your body (like your skin, digestive or reproductive organs) will be deprived of blood flow and nervous innervation. Hypoxic states can cause oxidative stress, which has been shown to be linked to autoimmunity, atherosclerosis and even cancer.

Knowing how prevalent obstructive sleep apnea is in our population, this connection is not surprising. Is there anyone reading this blog that had their psoriasis go away completely after your sleep apnea was treated?

Does Protandim® Increase Your Energy Level?

Well, yes.

…not because Protandim is a stimulant, it really isn’t. The caffeine content from green tea extract (one of the 5 ingredients) is so small, its barely measurable, the amount of caffeine found in a chocolate chip. The other ingredients are not stimulants, however some have been used as “brain food” or liver tonics for centuries. However, the real magic why Protandim gives people energy is because it lowers oxidative stress, so powerfully, that it frees the body to focus energy production in ways that we feel, instead of focusing energy into trying to repair the damage associated with oxidative stress.

Ever see kids bouncing around with energy? It’s the same thing, well ok some kids eat WAY too much sugar. If you can get the blood of a child back, this is what can happen to you. Of course this takes time in most people, since Protandim isn’t a stimulant, like energy drinks will do, it takes time for your body to heal itself. Most people see a bump of 50% to 100% increase in energy, if they’re work down. If one is healthy, it might be harder to tell, however, if you work out, you’ll notice a huge improvement in energy recovery time. The US special forces are currently studying this very thing, how Protandim can help solders recover from physical excursion.

So yes Protandim can do that… absolutely. If you watch TV shows like Dr Phil or Dr Oz, you will know that helping to reduce free radical damage in the body results in a big energy lift. This is what Donny Osmond says.

Donny Osmond Appears on Dr. Phil Show

LifeVantage spokesperson Donny Osmond appeared on the Dr. Phil show earlier this week and shared one of his “secrets” to his youthful appearance and vitality–Protandim! On the heels of Donny’s appearance, Protandim ranked first among Google searches in the United States February 8, and remained in the top among Google searches in the United States February 9. In addition to its Google trend ranking, LifeVantage.com visits were up nearly 300% and Protandim.com visits were up over 800% during the same time period.

Donny Osmond, the 2009 “Dancing with the Stars” champion, said he had discovered what he called his own “fountain of youth,” Protandim, during his appearance on the Dr. Phil show. Donny also stated that he has taken Protandim for two years. Prior to appearing on Dr. Phil, Donny has publicly shared that he began taking Protandim at his doctor’s recommendation and has experienced many health benefits and anti-aging results.

“This continues to be an exciting time for Protandim and LifeVantage,” said LifeVantage President and CEO, Douglas C. Robinson. “There is an ever-increasing number of Nrf2 studies in many of the most respected universities and institutions around the world. It is also gratifying to know that Protandim is of such interest that people have been typing ‘Protandim’ in Google searches more than any other word recently.”

See a segment of the show HERE

What Makes Protandim® Different?

Lots of people are curious about what makes Protandim different that other supplements. Does this replace vitamins? Can I take the individual ingredients and get the same effect? What about juice products that contain super-foods? How about shakes or other anti-aging products that might be on the market, including those that claim to support telomere support at the DNA level.

It’s actually quite simple. Protandim is the only supplement that has peer reviewed science (with very rare exception). Many company’s products (not limited to network marketing), support their products with what I call “borrowed” science. This means they’ll take research (in many cases peer reviewed), and borrow that research to claim their product is effective, even when the research is not about their product at all, maybe its ingredients or maybe just about a health condition related to inflammation or in the case of Protandim oxidative stress.

To some degree when we talk about Protandim we suggest people search pubmed.gov for topics about oxidative stress, or inflammation too, but there are 10 peer reviewed studies (or articles) that support the claim “protandim reduces the markers of oxidative stress, in everybody who takes it”.

Most people should continue to take a good vitamin supplement (and most vitamin supplements are not good sources, so pick a whole-food vitamin not chemical versions). However, any supplement such as C or E, or super foods that contain antioxidants for the purposes of reducing free radical damage are no longer needed, Protandim solves that problem much, much better.

Taking the individual ingredients of Protandim could produce the same effect, if you take the same amounts as found in Protandim. Taking too much of any one, or not enough of an other won’t do the same thing that Protandim does. Dr McCord has validated this in his research. You don’t have to believe him, but you should believe the research that was peer reviewed, and published. If you take too much of these individual ingredients, it can actually not work at all, so try not to ‘do it yourself’, its too much work, and you won’t save that much. If a supplement you currently take has one more more of the same ingredients, you might consider taking that supplement at a different time of day.

Super-foods are good, and should be taken for nutrition, but not for oxidative stress, they don’t work to do that. In fact many super juices actually increase oxidative stress, simply because its full of sugar, that as you convert it into energy, free radicals are simply the byproduct.

Elevated TBARS is a Strong Predictor of Cardiovascular Events

In resarch released some years ago, Serum levels of TBARS were strongly predictive of cardiovascular events in patients with stable CAD, independently of traditional risk factors and inflammatory markers. See: http://www.ncbi.nlm.nih.gov/pubmed/15542282

This means that Protandim proven to reduce TBARS, could be a very strong preventative measure against heart disease. This echo’s findings from the American Heart Association’s published article on Protandim back in 2009.

Is TBARS a valid measurement of oxidative stress? Yes. And it speaks volumes to the clinical effects of what Protandim can do.

Protandim® Study on Alcohol Use Disorders

The 10th Study as its being called, conducted at the University of Colorado/Denver, showed Protandim does not influence alveolar epithelial permeability or intrapulmonary oxidative stress in human subjects with alcohol use disorders.

The study sought to determine if correcting pulmonary oxidative stress in the setting of AUDs (alcoholism) would normalize alveolar epithelial permeability (BAL protein) in a double-blinded, randomized, placebo-controlled trial of Protandim. While the study did not prove to be statistically significant (meaning > 95% effective, and the purpose of the study), the study did show several interesting things.

First it showed that the Protandim was 77% more effective than the placebo treaded subjects, with an increase of endothelial permeability (BAL protein), which was completely eliminated in the Protandim treated subjects. Second, it confirmed TBARS was significantly lowered in this study. Third it was the first blinded, randomized, placebo study (and there will be more). And fourth the study showed no harmful effects with Protandim (granted, the study was not for that purpose, but it was noted).

This study was peer reviewed, and is out for publication.
see http://ajplung.physiology.org/content/early/2012/01/17/ajplung.00171.2011.reprint

An interesting thing to note too, candidates taking Protandim took it for 7 days, the recommended duration is 3-4 months for it to fully regulate Nrf2. A longer study will likely be conducted.

See: http://www.ncbi.nlm.nih.gov/pubmed/22268125

Pay Less than $40 for Protandim®

Some people cannot afford $40 per bottle (even though that’s not that much, really). Here is a suggestion. Take a half a pill per day. All you have to do is setup a preferred customer account, and call customer service, and ask them to send 1 bottle every other month. Taking a half a pill isn’t half the effect, its most likely 70% of the effect. 1 pill is better, but taking a half is a lot better than nothing. This works especially if you’re weight is say, less than 130.

That of course begs the question, should you take 2 pills per day, if you’re heavy. Well, unless your a professionally athletic, or severely sick, most likely 1 per day is fine. Or maybe if you’re really large, say over 300, but this is just my 2 cents from feed back I’ve been given.

Either way, a half a pill per day for some on a very tight budget, is not a bad option. Note: a half pill per day is better than 1 every other day.

Large Scale Protandim® Clinical Studies

One common question I get asked is why are there no large scale human clinical with Protandim?  The answer is pretty easy, but I have to answer this with some history.

When Dr McCord first formulated Protandim, he knew that it worked.. in vitro (test tube experiments) proved extremely positive.  The desire to see if this translated into something that would work with living people was strong. So to that end, a simple clinical was done, small scale, and included a few dozen people by random, largely those available to him at the university or in the lab.  He gave no instructions on how to take it, but simply take one pill per day.  The purpose ofthe study was to find out, what effect if any Protandim would have in vivo (in the living).

The results were remarkable.  Everybody in the study had their oxidative stress levels (as tested by TBARS) reduced to the level of a child.  We use the phrase 100% of the people 100% of the time, and this was the case.  The study was never meant to be a large scale FDA style study.  It was simply meant to see if Protandim would work in people. So the question remains, why not a larger scale clinical as we typically see with FDA studies that involve thousands?

From 2003 until (frankly now), the company was in debt.  The cost associated with an FDA large scale clinical would be financially exhaustive and literally impossible.  During the same period over 25 studies started being done by third parties, (with McCords assistance in some cases).  Because of the nature of the funding by those researchers are small, most chose mammal studies (like the LSU study) or in vitro studies (like the Ohio State study).  LifeVantage didn’t dictate to these researchers in what manner they will study Protandim’s effects with their subject of interest.

However, we do know some of these studies are human clinicals, and we wait for these results on the time-table determined by the peer review process.  However, we should not forget, the largest scale human clinical are the 10′s of thousands of customers who take Protandim who are not involved in the business.  While we don’t gather statistics on their experience, we should know that they’re experience is likely a positive one, else they would not continue to take Protandim with the attrition rates, and the huge positive feedback given.  Because the supplement industry is regulated, these testimonials rarely surface in public forums, yet these testimonials exist in spades.

So what will the future be with human clinicals and Protandim?  I suspect as the company grows (being cash flow positive) and research focus takes hold, investments in larger scale clinical will occur. We do know that other Nrf2 activator drugs like BG-12, are found to be very effective against Multiple Sclerosis, studies that compare in vitro Protandim to BG-12, show Protandim to be more effective, so, while no statistical conclusion is available (yet), the results look very promising with other large scale clinicals for Nrf2 activators (even if they are synthetics, Protandim being all natural).  In the months and years ahead, we’ll see many more studies come out that include Protandim, some will be clinicals.  Be patient, and be glad that the world doesn’t know about it yet.

Importance of Peer Review Studies

Peer Review in the scientific and medical community is critical for validation of the information in any particular study. A peer reviewed study means, the study is sent anonymously to a small handful of peers (can be 2 or 3 others), who review the content in the study, which may include, repeating the research or asking additional questions, that the authors must reply too, or if there are problems or inconsistencies, they must repeat or fix.

This peer review process is the gold standard in research, a study that is not peer reviewed, is never given consideration for publication, and frankly is considered sub-par to other researchers, medical professionals or labs. As a consumer you must know the difference, specifically as it pertains to network marketing in the health and wellness space.

One common practice (and its pervasive) is for a company to take an ingredient, that does have peer reviewed research, put that ingredient in some form into their product, and make claims that it has a lot of science behind it. In stark contrast however, Protandim has peer reviewed research on Protandim, not on its ingredients. And while there are hundreds if not thousands of peer reviewed studies on Protandim’s ingredients, there are as if this post, 9 peer reviewed studies or articles on Protandim itself, the composition as it is.

This is a major differentiator in the industry. Furthurmore, Protandim studies have been published in a range of medical journals, because not only have them been vetted by the peer review process, but they say something extraordinary. This vetting process also removes any conflicts that might have influenced the outcome of the research, because not only do the peers who do the review look for problems in the research, they also check who funded them, and look to make sure there is no problems in authorship or funding. And while LifeVantage has funded a few (not all) of the 9 for Protandim, this too has been vetted in the process.

Nrf2 Potency and Big Pharma

Drug companies are a bit late to the game, but they get it, but they also know they cannot just put a supplement out there, but they need to make a drug to make big money. If they can create a synthetic, even if there is a high amount of side effects it will sell, because Doctors know oxidative stress is a BIG deal. Look at what Reata/Abbott is doing:

http://www.news-medical.net/news/20111212/Reata-Abbott-partner-to-develop-and-commercialize-AIMs-for-chronic-diseases.aspx?page=2

AIMs are potent activators of the transcription factor Nrf2. Activation of Nrf2 promotes the production of a wide range of antioxidant, detoxification, and anti-inflammatory genes. Activation of Nrf2 also inhibits NF-KB, a transcription factor that regulates many pro-inflammatory enzymes. Suppression of Nrf2 and activation of NF-KB have been associated with numerous chronic diseases, including multiple sclerosis, rheumatoid arthritis, chronic kidney disease, neurodegenerative disease and COPD. Therefore, agents that activate Nrf2 and inhibit NF-KB may be beneficial in the treatment of these chronic diseases.

Then there is Protandim, that is more effective and will likely be cheaper, plus its all natural. Don’t believe me, read this peer reviewed study:
http://www.sciencedirect.com/science/article/pii/S0098299711000501

Protandim Nrf2

Protandim is not a drug, its not a synthetic, so drug companies cannot sell it at $200 per bottle like they need too. Instead you can buy Protandim from a LifeVantage distributor at $40, and its more effective. Now while there are no big human clinicals to show this yet, it does beg the question, what is the direction of this research, and how HUGE is this going to be?

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