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Multiple Sclerosis, Oxidative Stress and NRF2: What you Need to Know!

Multiple Sclerosis is an autoimmune disease that damages the nerves in the brain and spinal cord. This damage causes loss of muscle control, tingling of the nerves or numbness in the body. Vision and balance can also be negatively impacted. Sclerosis means the creation or buildup of scar tissue in the brain and spine. This buildup destroys the protective covering (myelin) around the nerves. This in turn interrupts the communications between the brain, spinal cord and other areas of the body.

Secondarily, the disease generates inflammatory-mediated reactive oxygen and nitrogen species within the body. Those that study Nuclear factor-erythroid 2-related factor 2 (Nrf2) know this has a negative impact on the production of protective antioxidant and detoxication enzymes within the cells.

The disease affects 400,000 plus Americans according to the WebMD website. Statistically more females are impacted by the disease than males. Prime ages for risk are between 20 and 50 years old.

Multiple Sclerosis Symptoms:

  1. Vision problems: Blurred and or double vision
  2. Eye pain
  3. Muscle weakness
  4. Coordination problems
  5. Muscle stiffness
  6. Bladder control problems

NRF2, Oxidative Stress and Multiple Sclerosis Studies

NRF2 activation or balancing may help MS patients in the following ways.

  1. Reduction or slowdown of scar tissue creation. NRF2 activation has been shown to reduce fibrosis in the body.
  2. Increased production of protective antioxidant and detoxication enzymes
  3. Nrf2 can modulate an autoimmune neuroinflammatory response
  4. A study published in Pharmacogenomics Journal (June 2012) showed NRF2 treatment worked best when consistently applied as opposed to once off “boost” treatments.
  5. Production of antioxidant genes regulate inflammatory cytokines and endogenous anti-oxidants which are variables affecting disease progression in multiple sclerosis (MS). In addition they exert neuroprotective effects directly.(See Sci Rep. 2011;1:201. Epub 2011 Dec 19)

Information provided on this site is for educational purposes only. Do your own research, and consult with a medical professional about your findings.

WATCH THIS VIDEO: http://www.youtube.com/watch?v=73JjfI3YorM

Pharmaceuticals: 1 Short, 1 Buy, 1 Strong Buy

By Mohsin Saeed - July 16, 2013 | Tickers: AXDX, LFVN, VRTX | 0 Comments

Mohsin is a member of The Motley Fool Blog Network – entries represent the personal opinion of the blogger and are not formally edited.

Biotechnology stocks are usually valued on the potential of their pipelines, especially if there is no drug already in the market. The ‘patent-cliff’ has increased the investor interest in promising pipelines, improving the valuations of small biotechnology companies. The increase in FDA approvals has also positively impacted the entire healthcare sector by encouraging investors to invest more heavily in pipeline stories.

A number of biotechnology companies have benefited from this investor goodwill, but are only few which truly deserve it. An effective method of singling out over-valued investments and exploring strong pipelines is to follow insider and institutional trades. 

Buy

Accelerate Diagnostics (NASDAQ: AXDX) is involved in the development and commercialization of bio-analytical measurement instruments and proprietary surface chemistry formulation. The company is working towards eradicating drug resistant organisms and hospital acquired infections. It offers the BACEEL and OTICHEM platforms for detection and coating technologies respectively.

It is currently trading near its 52-weeks high and has already appreciated 90% YTD. Insiders are also showing interest in company with Director Larry Fienberg adding almost 45,000 shares to his holding for the net amount of $379,151. During the last 6 months, institutional investors have also been showing a lot of interest in Accelerate. They have added almost 2.9 million shares to their portfolios, increasing institutional holdings by 34%.

Although there are no obvious catalysts which are driving up the share price of Accelerate, the confidence of insiders and institutions is a strong buy signal. In the last few months, shares have already rallied 90% and the heavy insider buying suggests it can go even higher.

Must Buy

LifeVantage (NASDAQ: LFVN) is a biotech involved in the discovery, development, and commercialization of nutraceutica dietary supplements. In the last 6 months, the shares have appreciated 14% due to significant improvement in sales. This improvement is due to better marketing and sales effort behind the company’s primary product Protandim. The product is a daily dietary supplement that combats oxidate stress through Nrf2 activation. The United States anti-aging market is huge with only anti-aging skincare  contributing $2.3 billion to sales.

The stock is currently trading at a forward P/E of 14x which is way below the industry average P/E. The sell side is expecting LifeVantage to double its EPS within the next two years; from $0.09 (current year) to $0.18 (2014). Insiders and institutional investors also share this positive sentiment. During the last six months, Insiders have purchased approximately 43000 shares and institutional investors have added 1.4 million shares to their portfolio. The net addition of 1.4 million shares has increased institutional share holdings by mammoth 22%.

The street is expecting LifeVantage to increase its EPS by 100% within the next couple of years. The market has still not realized the immense opportunity the company presents, and that is why the stock has moved up only 14%. Using a P/E of 24x and 2014 estimates of $0.18, we can set a $4.30 target on LifeVantage.

Bottom-line

The three companies above have seen heavy insider trading during the last six months. The revenues of Vertex are on a massive decline, and while the market is pumping it on pipeline strength, insiders don’t agree. This lack of insider confidence on the pipeline makes Vertex a terrific short target. Accelerate Diagnostics and LifeVantage have both shown solid fundamental improvements. Insiders and institutions are also increasing their holdings, which is a bullish signal for investors.

Nrf2/ARE Signaling Pathway: Key Mediator in Oxidative Stress and Potential Therapeutic Target in ALS.

Source:  Department of Neurology, Hannover Medical School, Hannover, Germany.

Abstract 

Nrf2 (pronounced “Nerf2) (nuclear erythroid 2-related factor 2) is a basic region leucine-zipper transcription factor.  It binds to the antioxidant response element (ARE) and thereby regulates the expression of a large battery of genes involved in the cellular antioxidant and anti-inflammatory defence as well as mitochondrial protection.  

(Translation: Nrf2 regulates the expression of genes, including antioxidant and anti-inflammatory ones.)

As oxidative stress, inflammation and mitochondrial dysfunctions have been identified as important pathomechanisms in amyotrophic lateral sclerosis (ALS), this signaling cascade has gained interest both with respect to ALS pathogenesis and therapy.   

(Translation: Oxidative stress and inflammation are key factors in the pathology of ALS.)

Nrf2 and Keap1 expressions are reduced in motor neurons in postmortem ALS tissue.  

Nrf2-activating compounds have shown therapeutic efficacy in the ALS mouse model and other neurodegenerative disease models.

Alterations in Nrf2 and Keap1 expression and dysregulation of the Nrf2/ARE signalling program could contribute to the chronic motor neuron degeneration in ALS and other neurodegenerative diseases.

Therefore, Nrf2 emerges as a key neuroprotective molecule in neurodegenerative diseases.

Our recent studies strongly support that the Nrf2/ARE signaling pathway is an important mediator of neuroprotection and therefore represents a promising target for development of novel therapies against ALS, Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD).

(Note from: Rebecca R. Riales, M.Ed., Ph.D., LPC-LPCC-NCC)     It’s a “connect the dots” situation. 

This article says that patients with neurodegenerative diseases including ALS are in great need of Nrf2 activation to protect and treat their nerves.

Other articles have proven that Protandim is a potent composition of highly synergistic phytochemical Nrf2 activators.  It has four U.S. patents … is highly effective, totally safe, has no drug interactions, and is reasonably priced.

If you know anyone who would be interested to learn that there’s a safe & effective product that helps in neurodegenerative diseases, keep me in mind, okay?  Thanks.

HaveYouTuned-upYourGenes Lately?  

Has aging been unkind to you? 

Would you like better genes?    

Has the economy been unkind to you? 

Would you like a better way?

Long-used, much-studied turmeric a key Protandim ingredient

When you first learned of Protandim, you probably researched to find out its ingredients. Some–maybe all–of these ingredients were new to you even though they’ve been used in other parts of the world for centuries.

One of Protandim’s five botanical ingredients is turmeric extract. Turmeric is a perennial plant of the ginger family Zingiberaceae. It grows in southern Asia, most specifically in India where it thrives in warm, humid temperatures and abundant rainfall.

Turmeric has been used in Chinese herbal medicine and by natives of India for more than 2,500 years, possibly much longer. The list of health conditions turmeric may help to alleviate is impressive. Research suggests it may be helpful for the following conditions:

 Indigestion
 Stomach ulcers
 Osteoarthritis
 Heart Disease
 Bacterial and viral infections
 Cancer
 Alzheimer’s disease

On its own, Turmeric is a weak Nrf2 activator; however, when it is combined with the other ingredients in the specially designed formulation, Protandim is a powerful Nrf2 synergizer.

Turmeric is also used to color cheeses, popcorn, cake icings, cereal, yogurt, dry mixes, salad dressings, margarine, mustard and chicken broth. It has also been used in India for wedding and religious ceremonies.

Scientists continue to study the effects and benefits of turmeric. You can enjoy its benefits along with those of four other ingredients in Protandim.

Eat Your Fruits and Vegetables, but Don’t Forget the Protandim

Remember when you were young and were constantly urged to eat plenty of fruits and vegetables? This sage advice is sound for anyone–young or old. 

Fruits and vegetables provide essential nutrients, and they are low in fat. Fruits contain high amounts of fiber, water and vitamin C; nutrition found in vegetables is considerable, with vitamins A, K and B6, provitamins, dietary minerals and carbohydrates. The USDA Dietary Guidelines for Americans recommends consuming three to five servings of vegetables and two cups of fruit daily.

Fruits and vegetables also contain antioxidants. Berries, grapes, oranges, plums and kiwi, among others, are sources, as is red cabbage, pepper and spinach. But nothing comes close to Protandim.

In order to neutralize the number of free radicals Protandim can neutralize each day, one would need to eat 375 oranges and 120 vitamin C tablets. Protandim induces the cells to produce enzymes that can eliminate 1 million free radicals per second. Protandim has been clinically proven to reduce oxidative stress by an average of 40 percent in 30 days.

So keep eating your fruits and vegetables for the many nutrients they provide. But to boost your antioxidants, take Protandim every day!

Protandim scam – dig the facts!

May be you’ve heard of the Protandim scam buzz too… Is it a really? Let’s figure out. Recent independent research from LSU suggested that this nutritional supplement called Protandim, might actually help prevent the risk of skin cancer. Originally, Protandim was known to heal skin tumor risk, which was discovered through some laboratory tests of LSU.

That research backs early discoveries of Dr. Joe McCord who researched and instituted that Protandim signals the body cells to generate antioxidants enzymes. This results into thousands of times higher power of the antioxidant compared to any food supplement or OTC supplement. And it’s the power which helps prevent oxidative stress when people keep aging.

Oxidative stress has been clinically proven as a key contributor to cancerous risk, heart disease or diabetes. In fact, the prime source of subsequent oxidative stress stems from free radicals that reside within our cells. Those free radicals literally “latch” on normal healthy cells to destroy them, which results into oxidative stress. Till a person reaches the age of 18 or so, the body is normally able to wrestle those free radicals by using its own supply of antioxidants.

But when we age, our body gradually loses the power of producing antioxidants. Thus its aging process is triggered and this can also result in other health issues like cancer, heart disease or diabetes. That’s why we see older people undergoing these complications much more than younger people.

Some clinical studies have dismantled the notion of Protandim scam, as Protandim has already been proven to significantly slow the body’s aging process along with other disastrous health issues. The scientists behind these researches are not claiming that Protandim offers a good cure for severe health complications or diseases. What independent studies show is that Protandim comes with special nutritional values which are really promising.

And most of all, Protandim isn’t any kind of consumable antioxident. Rather, it’s a kind of phytonutrient which is especially formulated to signal the body cells to generate effective antioxidant enzymes that in tern neutralizes much higher amount of free radicals (compared to conventional consumables).

The effectiveness of Protandim has been covered in the recent researches. But regarding the Protandim scam buzz, people keep making focused queries on whether this supplement is effective against heart disease. Well, technically speaking, if it’s capable of slowing down the body’s aging process through boosting the body’s antioxidants generation levels, then it is also likely to help prevent heart disease risks too – since such complications are related to the aging process as well.

Protandim – is it ‘the real’ anti-aging solution we’ve been looking for?

The scientists have described the aging process as a direct impact of oxidative stress on your body cells. This is however caused by disparaging molecules known as free-radicals. In our young age, the body is capable of fighting thee free-radicals efficiently as it has its own abundant supply of antioxidants.

But as we grow older, the body produces much more free radicals. Additionally, it is provided with much lesser supply of antioxidants for coping with the battles against aging or diseases. And that’s where an antioxidant booster like Protandim comes in. This antioxidant supplement has supplied lots of hope in the horizon. And users find it impressive too! At least that’s what you feel looking at the Protandim testimonials on the internet.

The fact that most of the common people are unaware of is that there are many types of antioxidants and they’re different in terms of functionality and characteristics. Let’s take a look at typical antioxidant supplements like vitamins A, Vitamin C and Vitamin E. Since the body readily consumes them, they’re popularly known to be “consumable” Antioxidants.

And also they’re known to be used up while neutralizing free radicals on a
one-by-one basis. True, such consumable antioxidants are widely available in the food you eat in your day to day lives. And you really want to know what brings so many Protandim testimonials these days? Protandim has a reputation of destroying millions of those malicious free radicals every second.

The exclusive blend of phytonutrients is found in Protandim and this signals the body genes to generate highly specialized antioxidant enzymes called SOD (Super Oxide Dismutase) and CAT (Catalase). These things work together as a system for your body’s flank against the free radicals. Such enzymes are highly “catalytic” and this means the SOD or CAT do not get used up while neutralizing the free radicals.

This means just one single caplet on a daily basis can create a cascade in the natural catalytic antioxidants of your body, which are capable of destroying millions of those free radicals every second. This goes on an ongoing basis – 24/7.

Another reason behind these Protandim testimonials is that this supplement sets realistic goals. It doesn’t claim that it’ll reverse the aging process and make people young again. And neither does it claim to keep people younger forever. Rather, it wants to let people age gracefully. Or putting it straight and simple, Protandim helps people live strong, fit and healthy as they age.


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